c. explain in molecular detail whether the mutations will
decrease or increase the polymerization tendency of hemoglobin
sickle:
c.1 Replacing Tyrosine at position 42 of the alpha chain with
Phe
c.2 Replacing His146 beta chain with Arg
c.3 Replacing Lys82 of beta chain with Ala
c.4 Replacing Val6 of beta chain with Ser





