immunodeficiency and infection
For each of the following conditions:
1) complement C8 deficiency: a defect that results in the
functional absence of the eighth complement cascade. C8 is involved in the
complement lytic pathway.
2) X- linked agammaglobulinaemia (Bruton’s disease) :This
affects an enzyme that is required for B cell development so pre B cells fail
to mature. The effect is very low levels of all classes of antibody, although T
cells mature normally. The condition is X- linked and therefore predominantly
affects boys.
3) Selective IgA deficiency: This is one of the more common
immunodeficiencies , affecting around 1 in 700 individuals. Those affected have
low IgA levels, but other immunoglobulin classes are normal as are T cells and
phagocytes.
QUESTION:
A) For each condition state what types of infection you
expect each of the above conditions the affected individual would be
susceptible to.
B) For each condition suggest why an individual would be
susceptible to the types of infections you listed in the question above (A).
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