1.

1. Define
   the term “genetic variation.”
2. If a
   gene or locus has two alleles (A and a) in a population, what are all
   the possible genotypes?
3. If the
   frequency of (A) allele = p, and the frequency of (a) allele is q, what
   is the frequency of all possible genotypes in this population?

2.

1. What is
   the Hardy-Weinberg equilibrium?
2. In a
   population, a locus A has two alleles (A) and (a). The frequency f of
   (A) is f (A) = 0.6; what is the f (a)?
3. Using
   these frequencies, calculate the frequencies of all possible genotypes
   in a population in Hardy-Weinberg equilibrium.

3.

1. In a
   population (Z), the frequencies of genotypes of a two allele locus (B
   and b) are f(BB) = 0.3, f(bb) = 0.6, f (Bb) = 0.1. Calculate the
   frequencies of both alleles.
2. Using
   the allele frequencies calculated in a., calculate the frequencies of
   all possible genotypes at this locus in a population after one
   generation of random mating.
3. Is the
   population (Z) in part a above in Hardy-Weinberg equilibrium? The
   population size is 1000.

4.

1. Describe
   how you would use the Hardy-Weinberg equilibrium to calculate genotype
   frequencies of a locus with three alleles.
2. If the
   f(D) of an X-linked gene in a population = 0.8, what is the f(d) of the
   other allele at this locus?
3. What is
   the frequency of females’ homozygous for d allele (X^dX^d)?
4. What is
   the frequency of males’ hemizygous for the d allele (X^dY)?

5.

1. Explain
   why more males present with X-linked recessive diseases. Show your
   reasoning.
2. Why must
   the five assumptions/criteria apply to a population before we can say it
   is in Hardy-Weinberg equilibrium?
3. Take any
   one of these assumptions and explain in detail how it could disrupt the
   Hardy-Weinberg equilibrium for a particular gene locus.