Part V of The Emperor of All Maladies brings us on a journey through history as we begin to understand how cancer is really a “distorted version of our normal selves” (page 363). The discovery of oncogenes (both viral and cellular), tumor suppressors, and the genetic basis of cancer introduced commonalities among many cancer diseases, leading to the development of the “Hallmarks of Cancer” by Hanahan and Weinberg. They have since also published an updated version of these ideas that includes additional emerging hallmarks, as well as “enabling characteristics” of cancer such as genome instability and tumor promoting inflammation (Hanahan and Weinberg 2011).
Based on this unit’s reading, how has your perception of cancer development changed? Should we be targeting hallmarks that define cancer (i.e. angiogenesis, resistance to apoptosis, replicative immortality), or should the focus be on targeting enabling characteristics that may set the stage for tumor development?
Hanahan D, Weinberg RA. 2011. Hallmarks of cancer: the next generation. Cell. 144(5): 646-674.
Link to paper: https://www.ncbi.nlm.nih.gov/pubmed/21376230
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