1. Figure 1 diagrams cGMP signaling (overview). In this diagram,
what are examples of:
a. First messengers
b. Second messengers
c. Receptors 2.
2) In Figure 1, what enzyme(s) controls the total levels of cGMP
in a cell?
3. In Figure 1, where would you expect to see signal
amplification?
4. In Figure 1, list at LEAST three points along the pathway
where you could imagine developing a method of inhibiting
(blocking) the end response.
NO GRCRs NPRs KG GC GTP 5′-AMP ATP CAMP Modulation of PDE activity cGMP Visual transduction 5′-GMP Phospho ation PKA Epac L Phosphorylation Beating of cardiac myocytes Relaxation of blood vessel Smooth muscle contraction inhibition of cell proliferation KA PDE Cell proliferation & apoptosis inhibition of platelet aggregation PK Cell differentiation & migration Gl mobility Insulin response immune response Neuronal function Airway distention Apoptosis Neuronal function Bone formation Reproduction etc. Figure 1. Overview of cGMP mediated signal transduction.
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