7. Using Figure 4, compare the structures of PDE5 to the other
PDEs, paying attention to the specificity and regulatory domains.
What do you notice about them? Which are more similar in structure?
Why?
Family Conserved Catalytic Regulatory Regions Domain Calmoduin binding Sbes cGMP binding sites cGMP-inhibited CAMP CGMP PDE UCR sites cGMP-binding sites speci PDE cGMP-binding sites cGMP pecific PDE am insensitive PDE CAMP BMX-insensitive PDE 10 cGMP-binding sites? CAMP PDE AcGMP Figure A. Structural domains of the PDE family.
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