A mutation causes a decrease in the activity of histone
deacetylase. Most likely histones would have a _______, and there
would be _______ in rates of transcription.

a) greater affinity for DNA; an increase

b) reduced affinity for DNA; an increase

c) reduced affinity for DNA; no change

d) reduced affinity for DNA; a decrease

The enzyme responsible for adding acetyl groups to histone
proteins is called

a) histone acetylase (HA)

b) histone acetylmethyltransferace (HAT)

c) histone acetyltransferase (HAT)

d) histone methyltransferase (HMT)

Addition of a benzopyrene adduct is the result of what type of
reaction?

a) alkylation

b) hydrolysis

c) oxidation

d) radiation

Point mutations in the DNA sequence do NOT cause _____
mutations.

a) silent

b) missense

c) frameshift

The addition of acetyl groups makes histones _______ positively
charged, and thus _______ their affinity for DNA.

a) more; increases

b) less; increases

c) less; has no effect on

d) less; decreases

If a mutation causes a decrease in the activity of histone
acetyltransferases, histones will most likely have a _______
affinity for DNA, and there would be _______ in transcription
rates.

a) greater; an increase

b) greater; a decrease

c) reduced; an increase

d) reduced; no change