AE Sapling Learning A problem known as the end-replication problem (telomere problem) exists in eukaryotic chromosomes wherein the chromosomes shorten with each round of DNA replication. Select the statements that best explain why the end-replication problem exists in eukaryotic chromosomes □ The lagging strand s synthesized from the hydroxyl end DNA ligase links the 5′ OH group of one fragment to □ DNA polymerase requires a primer for DNA synthesis. to the phosphate end. the 3 phosphate group of an adjacent fragment. DNA polymerase synthesizes DNA from the phosphate end to the hydroxyl end. The RNA primer is removed in a 3 to 5 direction.