Alpha thalassemia is a recessive trait in humans. Affected
individuals suffer from anemia, weakness, and fatigue. A man and a
woman are unaffected but are heterozygous for the normal and mutant
alleles i.e they are carries. Based on mendel’s law 1/4 of the
children are unaffected.

If they have five children, what is the probability of them
having one affected and four unaffected children, in any order?