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Question: As a genetic counselor, you are asked to assess the risk for a couple with a family history of re…

As a genetic counselor, you are asked to assess the risk for a
couple with a family history of retinoblastoma who are thinking
about having children. Both the husband and wife are phenotypically
normal, but the husband has a sister with familial retinoblastoma
in both eyes. Part A What is the probability that this couple will
have a child with retinoblastoma? Assume that familial
retinoblastoma is inherited as an autosomal dominant gene with 90
percent penetrance. Drag the appropriate labels to their respective
targets. Note: not all labels will be used.

Part B

Are there any tests that you could recommend to help in this
assessment?

Select the two correct answers.

A. Test for the presence of the RB gene in the
husband using molecular probes.
B. Check for the RB product in cells to see if
it is present and functional at normal levels.
C. Test the activity of the RB in the nucleus
of the cell.
D. Check the levels of the RB protein in the
husband’s cells.
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