As a genetic counselor, you are asked to assess the risk for a
couple with a family history of retinoblastoma who are thinking
about having children. Both the husband and wife are phenotypically
normal, but the husband has a sister with familial retinoblastoma
in both eyes. Part A What is the probability that this couple will
have a child with retinoblastoma? Assume that familial
retinoblastoma is inherited as an autosomal dominant gene with 90
percent penetrance. Drag the appropriate labels to their respective
targets. Note: not all labels will be used.
Part B
Are there any tests that you could recommend to help in this
assessment?
Select the two correct answers.
| A. Test for the presence of the RB gene in the husband using molecular probes. |
| B. Check for the RB product in cells to see if it is present and functional at normal levels. |
| C. Test the activity of the RB in the nucleus of the cell. |
| D. Check the levels of the RB protein in the husband’s cells. |
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