Aspartate transcarbamoylase (ATCase) it is a multimeric protein consisting of three separate catalytic domaine that are paired with three regulat pyrimidine synthesis that ultimately results in the formation of CTP. PALA mimics the structure of the transition state of the reaction. The regulatory domains along 5. ory domains. ATCase catalyzes the committed step in H2 N-Carbamoylaspartate with containng a CTP binding site contain ClobphayiAspartate an ATP binding site that stabalizes the R- state of the enzyme. 2- HO OH Cytidine triphosphate (CTP) N-(phosphonacetyl)-L-aspartate PALA) T state R state The following shows how CTP and PALA affect the state of the ACTase. What sort of regulation does ACTase follow? List any homotropic/heterotopic affectors or inhibitors. Do you expect any cooperativety? What type of inhibitor would PALA be? CTP PALA T state PALA