BCR vs TCR – how are they similar? Different? BCR TCR Antibody antigen-binding site Differences antigen-binding site Fab Fab Fc carbohydrate T-cell receptor TCR antigen-binding site Similarities antigen recognition α chain β chain CD3 CD3 variable region (V) constant region (C) transmembrane region cytoplasmic tail T cell signal transductiorn You’ll be able to add even more by the end of class. 6 Figure 54 The lemene Sptem, Sed. t0 Garland Scence 2909 Figure 5.1 The Immune System, 3ed. ( Garland Science