Binding of proteins to enhancers located far from the transcription start site regulates transcription by which of the following mechanisms? The protein binds to the enhancer and then “reads” along the DNA until it reaches the promoter. The DNA loops, bringing the enhancer and any bound protein(s) into the proximity of the polymerase. The protein recruits a co-factor which rearranges the histones. Protein binding leads to cutting out of intervening DNA.