Biochem Question #11

The human insulin receptor has a single transmembrane
alpha-helix (connected to large domains on both sides of the
membrane). The sequence of the transmembrane domain is shown
below:

a) Assume that the “nonpolar
hydrophobic core” of the E. coli membrane is 35 Å thick.
Draw a box around those residues that you predict would contact the
hydrophobic portion of the bilayer.

b) Circle the residues that could make favorable electrostatic
interactions with the phospholipid head groups. Briefly explain
your choices.