By 1926, the search to determine the
mechanism for genetic inheritance had reached the molecular level.
Previous discoveries by Gregor Mendel, Walter Sutton, Thomas Hunt
Morgan, and numerous other scientists had narrowed the search to
the chromosomes located in the nucleus of most cells. But the
question of what molecule was actually the genetic material had not
been answered.

         In 1928
Frederick Griffith came a step closer to answering this question in
a series of experiments with Diplococcus pneumonia
(bacterium responsible for pneumonia) and transformation
properties. Oswald Avery, Colin MacLeod, and Maclyn McCarty
(1934-1944) at the Rockefeller Institute, built on Griffith’s work
to show that deoxyribonucleic acid (DNA) was responsible.

1.What was the name of Frederick
Griffith’s famous paper discussing the pneumococcus bacterium in
1928? (Give full reference.)

2.Locate “Table 1” within Griffiths
paper. Explain a strength and a weakness of the table (this can be
format or content related).

3.What was the name of Oswald
Avery, Colin MacLeod, and Maclyn McCarty’s famous paper discussing
the transforming properties of DNA in 1944? (Give full
reference.)

4.Find the methods section on page
142. Give one strength and one weakness of Avery,

Macleod, and McCarty’s methods (this
can be format or content related).

5.How do these two papers relate to
the gene transformation experiment we conducted in our laboratory?
2pts

6.The structure of these older
primary literature papers is somewhat different than current
primary literature. Give 2 differences.