Critical thinking question

You are an oncologist asked to treat a patient with early stage
prostate cancer. During the course of a year, you found that the
tumor in the patient suddenly becomes much larger. You decided to
evaluate the status of candidate a tumor suppressor gene and make
interesting observations when testing the p53 gene and protein in
this patient by southern and western blots

What is your explanation for the observed result from Western
blot for the patient?

Propose reasons why such a change (missing p53 band) is
correlated with the large size of the tumor.

Do you think it would be good to treat patient 1 with a drug
that blocks blood vessel formation by angiogenesis?