DNA polymerases have conserved structures that are shared
amongst bacteria and eukaryotes. The structure of DNA polymerase is
similar to a “right hand.” Which of the following characteristics
of DNA polymerase is inaccurate? A. The “thumb” maintains contact
with the template and helps to hold the elongating duplex. B. The
“fingers” position nucleotides and “feed” the single-stranded
template into the palm. C. The “palm” contains the catalytic domain
responsible for the polymerization reaction to occur. D. The active
site does not require a specific “fit” for base-pairing of
nucleotides, which allows it to move very fast along the template
(highly processive). E. Magnesium ions stabilize the transition
state of the nucleophilic attack for the 3’OH of the existing
nucleotide on the 5’-phosphate of the incoming nucleotide.