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Question: Down’s syndrome can result from a Robertsonian translocation at a Frequency of 9/100 live births….

by | Dec 5, 2023 | Posted Questions

Question: Down's syndrome can result from a Robertsonian translocation at a Frequency of 9/100 live births....

Down’s syndrome can result from a Robertsonian translocation at a Frequency of 9/100 live births. This type of Down’s syndrome usually occurs in mothers that are less than 30 years of age. The Robertsonian translocation that leads to Down’s syndrome occurs between chromosomes 21 and 14. During Meiosis, three possible pairing configurations can be observed between the 14/21 translocated chromosome and the normal homologues. Think about how these pairings might occur and draw one of the three possible pairing arrangements. You should draw your pairing arrangements with respect to the equator of the cell at metaphase.

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