Fill in the blanks with the words provided in the word bank

___ a consequence of miss-matched HLA donor and recipient in a
bone marrow transplantation, where contaminating donor leukocytes
attack recipient’s tissues

___ a general pathogen associated structure recognized by
receptors of innate immunity

___ occurs in recipient of organ transplantation. In direct
form, receipt T cells interact with donor MHC on donor APCs

___ earliest complement activation pathway triggered directly by
pathogen surface

___ cytokine best known for its powerful inflammatory
effects

___ inflammatory chemical secreted by activated mast cells

___ a type of pathogen pattern recognition receptor that
activated innate immune response

___ expressed in activated B cells, this enzyme is essential for
isotype switching and affinity maturation.

___ cytokine that is best known for its ability to stimulate T
cell proliferation

___ regions within Ig and TCR variable segments that interact
with epitope.

___ state of T cell non-responsiveness to antigen that occurs in
absence of co-stimulatory signals.

___ blocks the antigenic peptide binding site of MHC class II
molecules in the endoplasmic reticulum