How do noncoding RNAs regulate epigenetic mechanisms during
development?
How do noncoding RNAs regulate epigenetic mechanisms during
development?
| Noncoding RNAs bind to chromatin-modifying enzymes and direct their activity to hypomethylated repetitive DNA sequences in heterochromatic regions, thereby increasing expression of the genes located there. |
| Noncoding RNAs regulate gene expression at the level of alternative splicing of primary RNA transcripts. |
| Noncoding RNAs bind to control elements within enhancers, stimulating formation of the transcription pre-initiation complex (PIC). |
| Noncoding RNAs reversibly convert euchromatic chromosome regions into facultative heterochromatin, silencing the genes located within these newly created heterochromatic regions. |
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