In a pedigree for an autosomal dominant disease of
accelerated tooth decay (TRN), each family member has been typed
for a four-allele DNA marker, as shown in the autoradiogram below
the pedigree. Using the results of DNA typing of offspring in the
third generation, calculate the distance between marker 1 and the
TRN gene by the LOD method. Present your calculation using Excel.
Present excel results in the graph. Excell Calculation:
Graph:
Conclusion (most probable distance in cM):
1,1 1.2 2.2 2,3 2.4 1.4 2,4 2.3 1.3 3.3 2.4 3,4 4,4