Malonate is a competitive inhibitor of succinate dehydrogenase. If malonate is added to a mitochondrial preparation that is oxidizing pyruvate as a substrate, which of the following compounds would you expect to decrease in concentration? a. Citrate b. Fumarate c. Isocitrate d. Pyruvate e. Succinate Which of the following does NOT contribute to the large, negative, free – energy change upon hydrolysis of ATP? a. electrostatic repulsion in the reactant. b. Energy release from cleavage of a high energy bond c. stabilization of products by extra resonance forms. d. stabilization of products by solvation (entropy effect). e. These all contribute to the free – energy change Each biochemical reaction has a characteristic free energy change Delta G’. Which of the following statements about AG’ is NOT true for a specific reaction? a. It depends on Delta G’ degree b. it depends on reactant concentrations c. it is the free energy change for biological systems d. It is the criterion for the spontaneity of a reaction e. More than one of the above are true