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Question: Maturity onset diabetes of the young or MODY refers to a series of congenital defects that cause …

by | Dec 5, 2023 | Posted Questions

Biochem question on diabetes and metabolic pathway
Question: Maturity onset diabetes of the young or MODY refers to a series of congenital defects that cause ...

Maturity onset diabetes of the young or MODY refers to a series of congenital defects that cause diabetes. Describe M0DY2 and permanent neonatal diabetes mellitus (caused by mutations in glucokinase and ABCC8/KCNJ11 genes respectively). Use your knowledge of pancreatic beta-cells, hepatocytes, metabolism, and regulation to answer this question. Also explain how these genetic disorders lead to diabetes. When thinking about glucokinase deficiency, suggest whether or not another hexokinase is able to replace glucokinase in the pancreatic beta-cell. Yes, you should google KCNJ11 and ABCC8. But only to find out what they are and how the mutation affects the normal protein.

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