Plese post with sources if possible

1.

True or False:

Kinases always turn on pathways

Phosphatases always turn off pathways?

Tyrosine phosphorylation is the only important target of
phosphorylation?

All cancers are the result of inappropriate activation
of tyrosine kinase?

Phosphorylated proteins can only carry one phosphate at
a time?

AND

The mutation in Jak which causes several
myeloproliferative diseases is located in the:

A. Kinase region essential for primary
phosphorylation

B. Pseudo kinase region involved in
regulation

What are neoantigens.