The response to epinephrine is
summarized below. (–> ) indicates activation or production, and
(–I) indicates inhibition.
Caffeine competitively inhibits cyclic
nucleotide phosphodiesterase, the enzyme that returns cAMP to AMP.
Explain the effect of combining epinepherine with caffeine on each
of the following:
Epinepherine levels
cAMP levels
PKA activity
Epinephenne → Epinephenne receptor→ Ga-Adenylyl cyclase→ cAMP-Protein Kinase A regulatory subunit-> Protein kinase A catalytic subunit (PKA) PKA ->Triacylglycerol lipase, glycogen phosphorylase PKA-Phosphofructokinase 2 pyruvate kinase, glycogen synthase
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