Please answer both questions thank you only answer

Which factor likely acts as a trigger for the spread of heterochromatin from its original site to adjacent DNA sequences? A. The activity of adjacent promoters. B. The activity of a methylase enzyme. C. The activity of an acetyltransferase enzyme. D. The concentration of transcription factors at a promoter. Mutations that occur in the promoters of genes that increase gene activity are said to be. A. up mutations. B. down mutations. C deletion mutations D impossible.