Which of the following statements concerning in vivo replication
of E. coli DNA are true? It may be necessary to circle more than
one answer.

A) The DNA is unwound as it is being replicated

B) Both daughter strands of DNA are synthesized in the 5′ to 3′
direction

C) RNA serves as a primer for the synthesis of both daughter
strands

D) The leading (continuous) strand is synthesized as short
fragments

E) Replication of the circular E. coli chromosome requires
telomerase

F) Okazaki fragments are covalently linked by DNA polymerase
I