Task 1 LO 4.1
a) (+) (-) and R/S are not equivalent ways of labelling optically isomers. Briefly explain the difference.
b) Most amino acids are chiral. Draw flying wedge diagrams to represent the R and S isomers of alanine and explain how you worked out which is the R isomer.
c) Fisher and Newman representaions are other methods of showing 3D structures.
Draw Fisher and Newman representations for the following.
i) R-2-bromopentane
ii) 3S,4R-dibromoheptane
iii) S-1-fluoro-2-chloropropane
Task 2 LO 4.1
a)
Optical Rotation
(+) glyceraldehyde
+ 8.7
(-) glyceraldehyde
– 8.7
Use the above data to calculate the optical rotation of a mixture containing the following percentages of enantiomers.
i) 60% (+) glyceraldehyde and 40% (-) glyceraldehyde
ii) 20% (+) glyceraldehyde and 80% (-) glyceraldheyde.
b) A mixture of two enantiomers has as observed rotation of -18째. The specific rotation of the (-) enantiomers is -27째. Find the % of the two enantiomers in the solution.
Task 3 LO 4.2
a) Select a chiral compound and explain how a mixture of the enantiomers can be separated using chiral chromatography.
b) Using a specific example explain how a chemical method or methods can be used to separate a mixture of enantiomers.
Task 4 LO 4.3
Enantiomers have identical physical and chemical properties, however this is not the case for diastereoisomers
a) Briefly explain the difference between diastereoisomers and enantiomers.
b) Tartaric acid has three stereoisomers, a pair of enatiomers and a diasterisomer (meso).
Research the different properties of the different stereoisomers of tartaric acid and write a short report. ( If you have an example of stereoisomers you would rather research you amy choose your own)
Task 5 LO 4.4
You are to research the synthesis and effect of an optically active compound on a biological system. Present your findings in a suitable format. PowerPoint presentation
Sugar
You should include information on:
Which optically…